Cell-based assays and instrumentation for screening ion-channel targets.
نویسندگان
چکیده
Ion channels are an important class of drug targets. They comprise the molecular basis for essential physiological functions including fluid secretion, electrolyte balance, bioenergetics and membrane excitability. High-throughput screening for ion-channel function requires sensitive, simple assays and instrumentation that will report ion channel activity in living cells. This article will review relevant assay technologies for ion channels and describe voltage-sensitive probes and instruments based on fluorescence resonance energy transfer (FRET) that enable ion-channel drug discovery.
منابع مشابه
High throughput assay technologies for ion channel drug discovery.
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عنوان ژورنال:
- Drug discovery today
دوره 4 9 شماره
صفحات -
تاریخ انتشار 1999